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EC number: 287-466-0 | CAS number: 85508-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No adverse effects were observed that could be related to the treatment with the test substance. Under the study conditions, the NOEL was greater than the highest dose tested and determined to be >2500 mg/kg bw/day.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Good quality
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A study was conducted to determine the repeated dose toxicity of the structural analogue (99.61% purity) according to EPA OTS Guideline 798.2650. Male and female Sprague Dawley rats (10/sex/dose) were administered by gavage the following concentrations (dissolved in corn oil, at a volume of 10 mL/kg bw): 0, 250, 1250 and 2500 mg/kg bw/day for five days/week during 13 weeks. The homogeneity, stability and concentrations of dosing suspensions were analysed and were within acceptable values. Mortality was checked twice daily. Clinical signs were recorded daily and detailed observations were realised once each week. Body weights and body weight gains and food consumption were measured weekly. Ophthalmic examinations (indirect ophthalmoscope) were made prior to the start of dosing and prior to sacrifice. Haematology following an overnight fasting (retro-orbital sinus) comprised measurements for AST, ALT, total protein, gamma glutamyl transferase, calcium, glucose, albumin, globulin (calculated), creatinine, total bilirubin, urea nitrogen, phosphorus, sodium, potassium and chloride. Clinical chemistry following an overnight fasting (retro-orbital sinus) comprised analyses of erythrocyte count and indices, haemoglobin, haematocrit, platelet count, total and differential leukocyte count. Gross pathology along with complete necropsy (gross examinations of lungs, liver, kidneys) were done for all animals. Organ weights were recorded for the liver, kidneys, spleen, brain with stem, heart, adrenals, testes and ovaries. Histopathology (lungs, liver, kidneys, spleen, trachea, oesophagus, stomach, intestine, brain with stem, eyes, exorbital lachrymal glands, zymbal glands, pituitary, salivary glands, heart and aorta, adrenals, thymic region, thyroid, nasopharyngeal tissues, vagina, mammary glands, testes and ovaries) was carried out on tissues saved in 10% neutral buffered formalin. Except for a blue coloration of the skin and/or tail of some animals, no adverse effects were observed that could be related to the treatment with the test substance. Under the study conditions, the NOEL was greater than the highest dose tested and determined to be >2500 mg/kg bw/day..
Justification for classification or non-classification
Based on the results of a repeated dose oral toxicity study in rat, no classification for this endpoint is required according to CLP (EC 1272/2008) criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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