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EC number: 272-745-1 | CAS number: 68910-55-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The 72-hour EC50 for the marine alga Skeletonema costatum was calculated in the original study report as 130.5 mg/L based on nominal Water Accommodated Fraction (WAF) concentrations. A re-analysis of the mean cell count data, reveals that the 17.8 mg/L concentration data are an outlier (i.e., mean cell counts at 24 h, 48 h, and 72 h are much lower at 17.8 mg/L than in both the next lower [10 mg/L] and next higher [31.6 mg/L] test concentrations). Therefore, a clear dose response relationship is not evident and a post-hoc analysis is warranted in accordance with OECD 201 guidance, ¶45, without the outlier data. Re-analysis of the data, results in an EC50 of 125.5 mg/L. In addition, organolignite's physical properties (i.e., low water solubility [54 µg/L] and dark brown/black color), suggest that the observed algal growth reduction is due to a physical effect and not a direct toxic effect.
Key value for chemical safety assessment
- EC50 for marine water algae:
- 125.5 mg/L
Additional information
The acute toxicity of the test substance, organolignite, to the marine alga, Skeletonema costatum, was determined using test method ISO 10253: 1998. Alga were exposed in static conditions for 72 hours to nominal water accommodated fractions (WAFs) containing concentrations of the test substance of 10.0, 17.8, 31.6, 56.2, 100.0, and 177.8 mg/L. The original study report calculated a 72 hour-EC50 of 130.5 mg/L, a LOEC of 17.8 mg/L, and a NOEC of 10 mg/L. A re-analysis of the mean cell count data from this study, reveals that the 17.8 mg/L data are an outlier (i.e., mean cell counts at 24 h, 48 h, and 72 h are much lower at 17.8 mg/L than in both the next lower [10 mg/L] and next higher [31.6 mg/L] test concentrations). Therefore, a clear dose response relationship is not evident and a post-hoc analysis is warranted in accordance with OECD 201 guidance, ¶45, without the outlier data. Re-analysis of the data, results in an EC50 of 125.5 mg/L, a LOEC of 177.8 mg/L, and a NOEC of 100 mg/L. In addition, organolignite is minimally soluble in water (54 µg/L), so the observed algal toxicity (at concentrations well above water solubility) are not expected to be due to direct toxicity, but a physical effect. Specifically, organolignite is a dark brown to black powder substance, which is expected to reduce the availability of photosynthetically active light and limit algal growth in a concentration-dependent manner.
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