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EC number: 268-358-2 | CAS number: 68081-84-5 This substance is identified by SDA Substance Name: C10-C16 alkyl glycidyl ether and SDA Reporting Number: 15-076-00.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the study results, it is concluded that the substance was not irritating to the skin of the rabbits.
The results indicated that the substance was not irritating to the eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1988-08-01 to 1988-08-05
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Cited from ECHA disseminated dossier Query date: 2015-07-22 For justification of read across please refer to IUCLID section 13.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 7 days
- Number of animals:
- 1 male and 2 females
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 hrs
- Score:
- >= 1 - <= 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Average score: 1.3
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Average score: 1
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Average score: 1
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 hrs
- Score:
- >= 0 - <= 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Average score: 0.3
Reference
Skin irritation scores:
Time period |
Animal |
Sex |
Erythema |
Edema |
Cumulative Score |
Mean Cumulative Score |
1HR |
4 |
M |
1 |
0 |
1 |
1.33 |
5 |
F |
1 |
0 |
1 |
||
6 |
F |
1 |
1 |
2 |
||
24HRS |
4 |
M |
1 |
0 |
1 |
1.33 |
5 |
F |
1 |
0 |
1 |
||
6 |
F |
1 |
1 |
2 |
||
48HRS |
4 |
M |
1 |
0 |
1 |
1 |
5 |
F |
1 |
0 |
1 |
||
6 |
F |
1 |
0 |
1 |
||
72HRS |
4 |
M |
2 |
0 |
2 |
1.33 |
5 |
F |
1 |
0 |
1 |
||
6 |
F |
1 |
0 |
1 |
||
7 DAYS |
4 |
M |
0 |
0 |
0 |
0 |
5 |
F |
0 |
0 |
0 |
||
6 |
F |
0 |
0 |
0 |
Skin irritation: mean scores
Animal |
Sex |
Erythema |
Edema |
Cumulative Score |
Mean Cumulative Score |
4 |
M |
1.33 |
0 |
1.33 |
1.22 |
5 |
F |
1 |
0 |
1 |
|
6 |
F |
1 |
0.33 |
1.33 |
Selected observations for mean scores: 24h, 48h and 72h.
Irritation
Alkyl (C13-C15)-glycidylether showed a primary irritation score of 1.22 when applied undiluted to intact rabbit skin.
Local signs (mean 1 hour to 7 days) consisted if grade 0.87 erythema and grade 0.13 edema.
Coloration
In the area of application no staining of the treated skin by pigment or coloring of the test article was observed.
Body weights
The body weight gain of all rabbits was similar.
Toxic symptoms / mortality
No acute toxic symptoms were observed in the animals during the test period, and no mortality occurred.
Necropsy
No necropsy was performed at termination of observation.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- From 1988-08-04 to 1988-08-11
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Cited from ECHA disseminated dossier Query date: 2015-07-22 For justification of read across please refer to IUCLID section 13.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 2 males and 1 female
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- other: Average score. 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 13
- Remarks on result:
- other: Average score: 0
Reference
Eye irritation scores:
Time |
Animal |
Sex |
Cornea opacity |
Iris |
Conjunctivae |
Cumul.Score |
Mean Cumul. Score |
|
Redn. |
Chem. |
|||||||
1HR |
27 |
M |
0 |
0 |
1 |
0 |
1 |
1.33 |
28 |
M |
0 |
0 |
1 |
1 |
2 |
||
29 |
F |
0 |
0 |
1 |
0 |
1 |
||
24HRS |
27 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
28 |
M |
0 |
0 |
0 |
0 |
0 |
||
29 |
F |
0 |
0 |
0 |
0 |
0 |
||
48HRS |
27 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
28 |
M |
0 |
0 |
0 |
0 |
0 |
||
29 |
F |
0 |
0 |
0 |
0 |
0 |
||
72HRS |
27 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
28 |
M |
0 |
0 |
0 |
0 |
0 |
||
29 |
F |
0 |
0 |
0 |
0 |
0 |
Results:
Toxic symptoms / Mortality
No acute toxic symptoms were observed in the animals during the test period, and no mortality occurred.
Irritation
Alkyl (C13-C15) glycidylether showed a primary irritation score of 0.33, when applied undiluted to the rabbit eye mucosa.
Coloration
No corrosion of the cornea was observed at any of the measuring intervals.
Body weights
The body weight gain of all rabbits was similar.
Necropsy
No necropsy was performed. All animals were killed and discarded.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation / corrosion
This study was conducted according to OECD guideline and EU method in order to evaluate the irritation potential of Alkyl (C13-C15) – glycidylether to the skin. 1 male and 2 female rabbits were used in the study. 0.5 ml of the substance was applied to the intact skin of the shaved areas of the each rabbit for 4 hours and the untreated skin areas of the rabbit serve as the control. All rabbits were examined for signs of erythema and oedema at 24, 48 and 72 hours after patch removal.
The results showed that the substance caused slight erythema during the examination period, however the reversibility of this reaction was observed at day 7 after the substance treatment. In addition the score for erythema and oedema formation can not meet the criteria of any category for skin corrosion/irritation under CLP.
Based on the study results, it is concluded that the substance was not irritating to the skin of the rabbits.
Eye irritation
This study was conducted according to OECD guideline and EU method in order to evaluate the risk potential of Alkyl (C13-C15) – glycidylether to the eyes. 2 male and 1 female rabbits were used in the study. 0.1 ml of the substance was placed in the conjunctiva sac of the left eye of each rabbit and the right eye served as control. Then the eyes were washed after 24 hours. The examination results showed that only slight erythema was observed in the three rabbits after 1h and no abnormalities were observed after 24h, 48h and 72h. The results indicated that the substance was not irritating to the eyes of rabbits.
Justification for selection of skin irritation / corrosion endpoint:
The results showed that the substance caused slight erythema during the examination period, however the reversibility of this reaction was observed at day 7 after the substance treatment. In addition the score for erythema and oedema formation can not meet the criteria of any category for skin corrosion/irritation under CLP.
Based on the study results, it is concluded that the substance was not irritating to the skin of the rabbits.
Justification for selection of eye irritation endpoint:
The examination results showed that only slight erythema was observed in the three rabbits after 1h and no abnormalities were observed after 24h, 48h and 72h. The results indicated that the substance was not irritating to the eyes of rabbits.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified as irritating for skin or eyes under Directive 67/548/EEC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for irritation under Regulation (EC) No. 1272/2008.
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