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EC number: 231-967-9 | CAS number: 7782-87-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-09-07 till 2009-09-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study in compliance to GLP standards
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: duplicate samples were taken from each treatment from the approximate middle of the aquaria without mixing the test medium
- Sampling time points: before the start of the test, after 48h and at the end of the test after 96h
- Sample storage conditions before analysis: immediately after sampling stored deep-frozen (about -20°C)
No more data available - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: 550.2 mg of the test substance was completely dissolved in 5.5 L of test water using ultrasonic treatment for 5 minutes and stirring for 15 minutes at room temperature. Test medium was freshly prepared just before introduction of the fish
- Evidence of undissolved material: none - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebra fish
- Source: breeding culture at Harlan Laboratories
- Length at study initiation: 2.7 +/- 0.10 cm
- Weight at study initiation: 0.13 +/- 0.01 g
- Feeding during test: no
ACCLIMATION
- Acclimation period: 1 week
- Acclimation conditions: same as test (test water and temperature)
- Type and amount of food: commercial fish diet (TETRA Min Hauptfutter, supplied by TETRA-Werke, Germany)
- Feeding frequency: feeding occurred during acclimation until one day before the start of the test
- Health during acclimation (any mortality observed): fish were healthy, no medication was applied, no fish died
No more data available - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 1.25 mmol/L (or 125 mg/L as CaCO3)
- Test temperature:
- 21°C
- pH:
- 7.5 - 7.8
- Dissolved oxygen:
- 8.4 mg/L - 8.7 mg/L
- Nominal and measured concentrations:
- Nominal concentration: 100 mg/L
Measured concentrations: ranged from 104 to 107% of the nominal value - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material: glass test vessel with 5L of test medium
- Aeration: slightly aerated
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.18 g fish wet weight/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted test water consisting of analytical grade salts dissolved in purified water (Millipore purification system) (composition see table 1 in other information on materials and methods).
- Alkalinity: 0.4
- Ca/Mg ratio: 4/1
- Na/K ratio: 10/1
- Intervals of water quality measurement: Water temperature, pH and dissolved oxygen were measured at the start of the test and once daily during the test for each treatment
OTHER TEST CONDITIONS
- Photoperiod: 16h light/8h dark (with 30 minute transition period)
- Light intensity: within range of 100 to 480 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable):
- Mortality: After 4, 24, 48, 72 and 96h.
- Visible abnormalities: After 4, 24, 48, 72 and 96h.
Visible abnormalities for which fish were observed: strongly extended gills, apathy, distended abdomen, fish mainly at the bottom of the test vessel, exophtalmus, convulsions, fish mainly at the water surface, mucus secretion, fish lying on side or back on the bottom, strong ventilation, tumbling during swimming, changed body color.
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: nominal concentrations of 0, 1.0, 10 and 100 mg/L
- Results used to determine the conditions for the definitive study: the range finding study showed that for all treatments the fish mortality after 96h was 0%, all fish appeared normal and the test medium appeared clear and had a constant test substance concentration - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: visible abnormalities
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: visible abnormalities
- Details on results:
- - Behavioural abnormalities: none
- Other biological observations: none
- Mortality of control: none
- Other adverse effects control: none
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: none - Reported statistics and error estimates:
- No statistics could be performed as no mortality was observed during the entire test period.
- Validity criteria fulfilled:
- yes
- Conclusions:
- In the test conditions, neither visible abnormalities nor mortality was observed during a limit test of 96h. Hence the LC50, and LOEC at 96h are above 100 mg/L and NOEC for 96h is equal or above 100 mg/L. Hence, the test substance can be considered non hazardous to the aquatic environment according to the CLP regulation (EC) n° 1272/2008.
- Executive summary:
The authors tested the acute toxicity of Sodium hypophosphite (CAS number 10039-56-2) to zebra fish (Brachydanio rerio) according to the OECD guideline 203 (Fish, Acute toxicity test) and according to the EU Method C.1 (Acute toxicity for fish). They performed a static freshwater limit test during 96h. The test included 1 test vessel and 1 control vessel each containing 7 zebra fish. After 4h, 24h, 48h, 72h and 96h the fish were observed and mortality and visible abnormalities was noted. Furthermore the concentration of the test material as well as the pH, temperature and dissolved oxygen was checked regularly during the test period.
Under these testing conditions no visible abnormalities or mortality was observed. Hence the LC50, and LOEC at 96h are above 100 mg/L and NOEC for 96h is equal or above 100 mg/L. The exact values of these parameters cannot be quantified due to the absence of toxicity of the test substance at the tested concentration (limit test: 100 mg/L). Hence, the test substance can be considered non hazardous to the aquatic environment according to the CLP regulation (EC) n° 1272/2008.
This study was performed according to OECD guideline and in compliance with GLP standards (certificate included) and all validity criteria were fulfilled, therefore, the study can be consided reliable without restrictions.
Reference
Description of key information
Acute toxicity of sodium phosphinate to zebra fish (Brachydanio rerio) was tested according to the OECD guideline 203 and according to the EU Method C.1. The static freshwater limit test included 1 test vessel and 1 control vessel and total duration was 96h. After 4h, 24h, 48h, 72h and 96h the fish were observed and mortality and visible abnormalities was noted. Furthermore the concentration of the test material as well as the pH, temperature and dissolved oxygen was checked regularly during the test period. No visible abnormalities or mortality were observed. Hence the LC50 and LOEC at 96h are above 100 mg/L and NOEC for 96h is equal or above 100 mg/L. The exact values of these parameters cannot be quantified due to the absence of toxicity of the test substance at the tested concentration (limit test: 100 mg/L). Furthermore, the measured concentrations of the test substance ranged from 104 to 107% of the nominal value. By read-across, potassium phosphinate 96h-LC50 is considered higher than 100 mg/L for fish.
Key value for chemical safety assessment
Additional information
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