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Diss Factsheets
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EC number: 231-388-1 | CAS number: 7526-26-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in soil
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in soil: simulation testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please see "Read-across Justification" section 13
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Remarks on result:
- other: Publication about the C-P cleavage potential of Agrobacterium radiobacter (isolated from sewage sludge) in Methylphosphonic Acid (MPA), which is a metabolite of Diphenyl methylphosphonate (DPP).
- Transformation products:
- not measured
- Details on transformation products:
- No details available.
- Evaporation of parent compound:
- not measured
- Volatile metabolites:
- not measured
- Residues:
- not measured
- Details on results:
- Pi supported the most rapid growth of Agrobacterium radiobacter, the specific growth rate was determined as 0.26/h.
A. radiobacter executes more C-P bond cleavage than necessary to attain its Pi requirements. A greater gas production was observed with substrates that supports higher growth rates. The major gaseous product was Methane (CH4).
Furthermore it is reported, that several Escherichia coli laboratory strains grew on methylphosphonic acid, suggesting that C-P lyase activity is not a trait that is readily lost during laboratory culture. - Results with reference substance:
- Many substances were investigated, but no specific reference substance. Growth was scored as a percentage of the final absorbance attained during the same period as the test substance by a Pi (inorganic phosphorous) control.
- Conclusions:
- Publication about the C-P cleavage potential of Agrobacterium radiobacter (isolated from sewage sludge) in Methylphosphonic Acid (MPA), which is a metabolite of Diphenyl methylphosphonate (DPP).
- Executive summary:
Wackett et al. (1987) investigated the carbon - phosphorus (C-P) bond cleavage by Agrobacterium radiobacter in Methylphosphonic acid (MPA), which was found to be a metabolite of Diphenyl methylphosphonate (DPP). A. radiobacter was isolated from sewage sludge from a water treatment plant. After four successive enrichment cultures, bacteria were streaked onto nutrient agar plates. Strains were selected for taxonomic identification were examined by Gram staining and then inoculated into API-E and API-NFT test strips. The identification of the selected bacterium was confirmed by its uniquely positive result on 3-ketolactose indicator plates. Many substances were investigated, but no specific reference substance. Growth was scored as a percentage of the final absorbance attained during the same period as the test substance by a Pi (inorganic phosphorous) control. Pi supported the most rapid growth of A. radiobacter, the specific growth rate was determined as 0.26/h. The bacterium executes more C-P bond cleavage than necessary to attain its Pi requirements. A greater gas production was observed with substrates that supports higher growth rates. The major gaseous product was Methane (CH4). Furthermore it is reported, that several Escherichia coli laboratory strains grew on methylphosphonic acid, suggesting that C-P lyase activity is not a trait that is readily lost during laboratory culture.
Reference
Description of key information
Experimental result with MPA (Metabolite of DPP): C-P bond cleavage by Agrobacterium radiobacter: more bond cleavage is executed than necessary for Pi requirements. The major gaseous product was Methane.
Key value for chemical safety assessment
Additional information
Wackett et al. (1987) investigated the carbon - phosphorus (C-P) bond cleavage by Agrobacterium radiobacter in Methylphosphonic acid (MPA), which was found to be a metabolite of Diphenyl methylphosphonate (DPP). A. radiobacter was isolated from sewage sludge from a water treatment plant. After four successive enrichment cultures, bacteria were streaked onto nutrient agar plates. Strains were selected for taxonomic identification were examined by Gram staining and then inoculated into API-E and API-NFT test strips. The identification of the selected bacterium was confirmed by its uniquely positive result on 3-ketolactose indicator plates. Many substances were investigated, but no specific reference substance. Growth was scored as a percentage of the final absorbance attained during the same period as the test substance by a Pi (inorganic phosphorous) control. Pi supported the most rapid growth of A. radiobacter, the specific growth rate was determined as 0.26/h. The bacterium executes more C-P bond cleavage than necessary to attain its Pi requirements. A greater gas production was observed with substrates that supports higher growth rates. The major gaseous product was Methane (CH4). Furthermore it is reported, that several Escherichia coli laboratory strains grew on methylphosphonic acid, suggesting that C-P lyase activity is not a trait that is readily lost during laboratory culture.
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