Registration Dossier
Registration Dossier
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EC number: 224-460-9 | CAS number: 4368-56-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 23, 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- ca. 21.35 g/L
- Temp.:
- 20 °C
- pH:
- ca. 8.07
- Conclusions:
- Water solubility is 21350 mg/L at 20°C and pH 6.60.
- Executive summary:
Method
The water solubility was determined by means of the shake flask method as per recommendations of OECD TG 105.
Result
The solubility of the substance is 21350 mg/L at 20°C and pH 6.60.
Reference
Preliminary solubility result: reference samples and extract were first measured in the range 190/800 nm, so as to choose the right wavelength for quantitative measurements.
Since absorbance of the test solution kept the same proportions along the UV and visible spectra, preliminary test result was considered for the final results calculations. Wavelength chosen was 637.00 nm.
Test results: reference solutions were measured in the spectrophotometer in quantitative mode, thus generating a calibration curve. Calibration curve was smooth and linear at every concentration. Considering that preliminary test resulted in an absorbance keeping the same shape like the references, its value was considered for the 24 hours’ measurement. Adjusting concentrations in proportion to the real weights the following results were obtained:
| Test 1 (24 hrs) | 21.90 | g/l |
| Test 2 (48 hrs) | 21.08 | g/l |
| Test 1 (96 hrs) | 21.05 | g/l |
| Average solubility | 21.35 | g/l |
| Standard deviation | 0.34 | |
| pH mother solution | 6.60 | |
| pH saturated solution | 8.07 |
Description of key information
Shake Flask Method - OECD TG 105: 21350 mg/L at 20°C and pH 6.60.
Key value for chemical safety assessment
- Water solubility:
- 21 350 mg/L
- at the temperature of:
- 20 °C
Additional information
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