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EC number: 206-167-8 | CAS number: 305-72-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 - 26 January 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- see principles of method if other than guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Regulation (EC) No 440/2008
- Deviations:
- yes
- Remarks:
- see principles of method if other than guideline
- Principles of method if other than guideline:
- Due to very high water solubility of the test item, estimated in a preliminary test, a modified TG OECD 105 design was conducted. Instead of equilibrating large amounts of test item (about five times in excess) with water by stirring over several days and subsequently separating the test item from the saturated solution, water was added in a stepwise procedure to a defined amount of test item until complete dissolution occurred.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Disodium 2-oxoglutarate
- EC Number:
- 206-167-8
- EC Name:
- Disodium 2-oxoglutarate
- Cas Number:
- 305-72-6
- Molecular formula:
- C5H6O5.2Na
- IUPAC Name:
- disodium 2-oxopentanedioate
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Oxidane
- Test material form:
- solid: crystalline
- Remarks:
- Crystalline powder
- Details on test material:
- Batch No: 14152300
Storage: 15 – 25 °C
Constituent 1
impurity 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- >= 511 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 23 °C
- pH:
- 7.5
- Details on results:
- The preliminary test indicated a water solubility of >=500 g/L, as 0.1 g were completely dissolved in 0.2 mL of ultra-pure water.
Main test
The results are given in the table in the next section. The water solubility was determined as the mean of the replicates analysed with HPLC. As this method does not ensure complete saturation of the solution, it is given as minimum value in mass per volume of solution. The test is satisfactory, if the concentrations of the three vessels do not differ by more than 15%.
Any other information on results incl. tables
HPLC determinations:
Test vessel | pH | Analysed concentration A (g/L) | Analysed concentration B (g/L) | Mean (g/L) |
No. 1 | 7.5 | 501 | 516 | 509 |
No. 2 | 7.5 | 520 | 516 | 518 |
No. 3 | 7.5 | 503 | 507 | 505 |
Overall Mean | 511 |
The concentrations of the three vessels differed by 3% (validity criterion given by OECD is met).
Applicant's summary and conclusion
- Conclusions:
- The water solubility of a-Ketoglutarate disodium salt (CAS no. 305-72-6) was determined according to a modified TG OECD 105 design.
The water solubility of the test item at 23°C was >=511 g/L. The pH of the aqueous samples was 7.5. - Executive summary:
The water solubility of a-Ketoglutarate disodium salt (CAS no. 305-72-6) was determined according to a modified TG OECD 105 design.
To this end, increasing volumes of water were added in a stepwise procedure, to approximately 1 g of the test item at 22 ± 2 °C until complete dissolution, which occurred after addition of 1.4 mL of water. The concentration of test item was subsequently determined by HPLC with UV detection. The determined water solubility of a-Ketoglutarate disodium salt is >=511 g/L at pH 7.5 and at 23 °C.
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