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Diss Factsheets
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EC number: 200-877-1 | CAS number: 75-54-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.1 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 150
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.1 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 150
- Modified dose descriptor starting point:
- NOAEC
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 12.6 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- Overall assessment factor (AF):
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 12.6 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- Overall assessment factor (AF):
- 1
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.2 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 300
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.2 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 300
- Modified dose descriptor starting point:
- NOAEL
Local effects
Long term exposure
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Additional information - workers
Dichloro(methyl)silane hydrolyses very rapidly in moist air and in contact with tissues to form hydrogen chloride (HCl) and methylsilanediol. Local effects (corrosion) are therefore influenced by the formation of HCl, while systemic effects may occur following exposure to the silanol hydrolysis product.Hydrogen and chloride ions will enter the body’s natural homeostatic processes and will not influence the systemic toxicity of the parent substance.
There are no adequate data regarding the repeated dose toxicity of dichloro(methyl)silane itself, therefore the properties of the hydrolysis products hydrogen chloride and methylsilanediol are considered appropriate to determine local and systemic DNELs for the parent substance.
No data are available for methylsilanediol, therefore long-term mammalian toxicity data for the closely related structural analogue dimethylsilanediol are used. This surrogate substance replaces an –H with –CH3. Both analogues have similar physicochemical properties (log Kow<0; water solubility >1E+06 mg/l; vapour pressure >20,000 Pa). Furthermore, the two parent substances dichloro(methyl)silane and dichloro(dimethyl)silane show similar effects in acute toxicity tests. It is therefore considered valid to read-across from dimethylsilanediol to methylsilanediol, and hence from dichloro(dimethyl)silane to dichloro(methyl)silane.
Hydrogen chloride (HCl)
An EU long-term inhalation Occupational Exposure Limit (OEL) has been set for HCl as 8 mg/m3(8 h TWA) in Commission Directive2000/39/EC.
The SIDS Initial Assessment Report (SIAR) for HCl describes a systemic NOAEL of 20 ppm from a 90-day repeated dose inhalation study (OECD, 2002). However, since the NOAEL for local effects in the same study was 10 ppm it is considered that the observed effects at 20 ppm were secondary to corrosion and were not indicative of true systemic toxicity.
It is therefore considered appropriate to use the existing EU OEL for HCl as the starting point to quantify local DNELs for dichloro(dimethyl)silane.
Dimethylsilanediol
In an OECD 422 study with dimethylsilanediol, Sprague-Dawley rats were dosed for 28/29 days in the toxicity phase of the study. The NOAEL was determined to be 250 mg/kg/day, based on hepatic protoporphyrinosis in males at the higher dose of 500 mg/kg bw/day. There are no reliable repeated dose toxicity data for the dermal and inhalation routes.
It is considered appropriate to use the NOAELs from the OECD 422 study on dimethylsilanediol as the starting point to quantify systemic DNELs for dichloro(methyl)silane.
In the absence of any findings relating to reproductive or developmental endpoints in appropriate screening tests, the critical health effect is considered to be repeated dose toxicity. Dichloro(methyl) is not classified as mutagenic, carcinogenic or sensitising.
The DNELs used for risk characterisation are therefore:
DNEL (long-term, inhalation): 4.1 mg/m3
DNEL (long-term, dermal): 1.2 mg/kg/day
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
There are no consumer uses of dichlorodimethylsilane, and no potential for exposure to humans via the environment. It is therefore not necessary to calculate DNEL values for the general population.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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