Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 432-840-2 | CAS number: 220926-97-6
Acute Toxicity: dermal
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- humidity value below the range (24 %)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Principles of method if other than guideline:
- Not applicable
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Any other information on results incl. tables
Table 7.2.3./2: Number of animals dead and number with evident toxicity
Dose (mg/kg bw) |
Conc. In vehicle (% w/v) |
Mortality (dead/total) |
Time range of deaths (hours) |
Number with evident toxicity |
||||
Male |
Female |
Combined |
Male |
Female |
Combined |
|||
2000 |
50 |
0 |
0 |
0 |
- |
0 |
0 |
0 |
Table 7.2.3./3: Mean irritant/corrosive data at 24, 48 and 72 -hour observations
Score at time point / Reversibility |
Erythema (mean score) Max. score: 4 |
Edema (mean score) Max. score: 4 |
24 h |
1.2 |
0.9 |
48 h |
0.6 |
0.3 |
72 h |
0.4 |
0.3 |
Average 24h, 48h, 72h |
0.73 |
0.5 |
Reversibility |
c* |
c* |
Average time (unit) for reversion |
Day 7 |
Day 7 |
c =completely reversible
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
