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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Guideline study

Data source

Materials and methods

Type of assay:
bacterial reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Method

Species / strain
Species / strain / cell type:
other: sat TA 98, TA 100, TA 102, TA 1535, TA 1537
Metabolic activation:
with and without
Metabolic activation system:
Aroclor rat liver S9-mix

Results and discussion

Test resultsopen allclose all
Species / strain:
other: sat TA 98, TA 100, TA 102, TA 1535, TA 1537
Metabolic activation:
with
Genotoxicity:
positive
Remarks:
weak positive effect on strain TA 1537
Species / strain:
other: sat TA 98, TA 100, TA 102, TA 1535, TA 1537
Metabolic activation:
without
Genotoxicity:
negative
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
positive with metabolic activation
negative without metabolic activation