Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Additional information:

Skin sensitization potency was examined in tests with 10 guinea pigs using test methods which are no longer in use and which are incompletely documented (Rusakov 1973): In a modified Draize test induction was performed with a 1 % acetone-solution of the compound on the shaved back for 5 consecutive days. At day 7 a challenge was performed with the same solution. As there was no skin reaction observed, a modified Freunds complete adjuvant test was performed: the same guinea pigs were treated with a 10 % solution of 1-chloro-2-nitrobenzene at day 22: 0.2 mL Freunds Adjuvans together with 0.5 mg 1-chloro-2-nitrobenzene/kg bw was injected into the hind paw. 6 days later one drop of a 10 % solution of 1-chloro-2-nitrobenzene was applied on the shaved untreated skin as challenge. The author reported that 50 % of the treated guinea pigs showed a positive reaction.


Migrated from Short description of key information:
Due to the limited and poor quality information available regarding skin sensitization it cannot be concluded whether or not the chemical has a sensitizing activity.

Respiratory sensitisation

Endpoint conclusion
Additional information:

Rats exposed via inhalation to 0.008 mg/m3for 5 months showed also positive reactions (see above; Rusakov et al. 1973).


Migrated from Short description of key information:
Due to the limited and poor quality information available regarding respiratory sensitization it cannot be concluded whether or not the chemical has a sensitizing activity.

Justification for classification or non-classification

Due to the poor quality of the data, a conclusion regarding classification for skin or respiratory sensitising properties cannot be made.