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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Individual animal data and information on GLP is missing.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1991
Reference Type:
other: OECD SIDS
Title:
1-Chloro-2-nitrobenzene, CAS: 88-73-3
Author:
OECD SIDS
Year:
2001
Bibliographic source:
SIDS Initial Assessment Report for SIAM 13

Materials and methods

Principles of method if other than guideline:
5 rats/dose (2 male and 3 female, or 3 female and 2 male), single oral dose as 10 % warm solution, observation time: 7 days.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Purity 99.71%

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
Concentration of the test material in the vehicle: 10%.
Doses:
398, 501, 631, 794 mg/kg bw
No. of animals per sex per dose:
5 per dose (2 males and 3 females at 398 and 631 mg/kg bw; 3 males and 2 females at 501 and 794 mg/kg bw).
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
560 mg/kg bw
Based on:
test mat.
Mortality:
398 mg/kg bw: 1 male, 0 females
501 mg/kg bw: 1 male, 1 female
631 mg/kg bw: 2 males, 2 females
794 mg/kg bw: 3 males, 2 females
Time of death: 1-4 days after dosing with most deaths within 2 days.
Clinical signs:
Reduced appetite and activity(2-3 days in survivors), increasing weakness, ocular discharge, collapse.
Gross pathology:
Decedents: hemorrhagic lungs, jaundiced liver, darkened kidneys and spleen, gastrointestinal inflammation.
Survivors: lung congestion and darkened kidneys and spleen.

Applicant's summary and conclusion