Registration Dossier
Registration Dossier
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EC number: 700-840-4 | CAS number: 160583-22-2
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Data source
Materials and methods
Results and discussion
Effect levels
- Basis for effect level:
- other: Study technically not feasible: test substance polymerizes immediately.
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Study technically not feasible: test substance polymerizes immediately.
Applicant's summary and conclusion
- Conclusions:
- Study technically not feasible: test substance polymerizes immediately.
- Executive summary:
Tests in aqueous media with 2-phenylethyl cyanoacrylate with the intent to determine effective concentrations or no effect concentrations can not be performed due to technical reasons based on the chemical properties of the monomer. In presence of moisture 2 -phenylethyl cyanoacrylate polymerizes within seconds (inherent property of cyanoacrylate based instant glues). Thus, very low determined monomer concentrations in water represent a non steady state situation from which a defined effective concentration can not be derived. Oral administration would be the most appropriate way. The monomer would polymerize in the oral cavity or when administered by gavage in the stomach. The application in the feed is not possible as the monomer polymerizes immediately on contact with food. This would allow only the polymer to be tested.
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