Registration Dossier

Administrative data

Endpoint:
dermal absorption in vitro / ex vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study cited by: CIR, 2011. Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics. Final Safety Assessment.

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
2009

Materials and methods

GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Radiolabelling:
no

Administration / exposure

Vehicle:
other: 10% in Hanks’ buffered salt solution
Details on in vitro test system (if applicable):
Two human skin samples from each of three donors were used in the study (n=6). The receptor fluid was Krebs ringer’s bicarbonate buffer without HEPES and glucose.

Results and discussion

Total recovery:
After 24 h, the mean recovery was 0.52% of caprylyl/capryl glucoside from two tape strips and 0.30% of caprylyl/capryl glucoside in the further 18 tape strips. The mean amount of caprylyl/capryl glucoside removed from the skin (by washing) ranged from 109-145% of the dose applied. The mean absorbed dose of caprylyl/capryl glucoside, as the sum of the amounts found in the viable epidermis, dermis, and receptor medium, was 0.01%.

Applicant's summary and conclusion

Conclusions:
The mean absorbed dose of caprylyl/capryl glucoside, as the sum of the amounts found in the viable epidermis, dermis, and receptor medium, was 0.01%.
Executive summary:

The dermal penetration of caprylyl/capryl glucoside was evaluated in vitro using human skin. The mean absorbed dose, as the sum of the amounts found in the viable epidermis, dermis, and receptor medium, was 0.01%.