Registration Dossier
Registration Dossier
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EC number: 434-800-1 | CAS number: 121776-33-8
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
MON 13900 did not hydrolyze in sterile aqueous solution at pH 5, 7 or 9.
Key value for chemical safety assessment
Additional information
A study was performed to determine the hydrolysis potential of MON 13900 according to EPA Guideline Subdivision N 161-1 in compliance with GLP. A mixture of 14C- and 13C-test substance was formulated in acetonitrile and added to sterile aqueous solutions (buffered to pH 5, 7 or 9) at concentrations of 58.15, 58.19 and 60.07 mg/L, respectively. The test solutions were maintained in the dark at 25°C for 28 d. Duplicate samples were collected after 0, 7, 14, 21 and 28 d and radioactivity was determined by LSC. Metabolites were characterized by HPLC/RAD. Mean total recoveries were 100.7%, 101.1% and 100.7% in the pH 5, 7 and 9 buffered solutions, respectively. Total radioactive residue and test substance concentrations remained constant throughout the study, as did the pH. Under the study conditions, the test substance did not hydrolyze in sterile aqueous solution at pH 5, 7 or 9.
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