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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test was conducted according to OECD 423 and compliant with GLP. Read-across from supporting substance (structure analogue or surrogate). Test substance (source substance): CAS No. 135452-43-6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
yes (incl. certificate)
Test type:
acute toxic class method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
rat
Strain:
other: Crl: CD (SD)
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Doses:
Six female animals were dosed with 2000 mg/kg test item by oral gavage in a dose volume of 20 mL/kg.

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality occured during study period (Day 1 to Day 14).
Clinical signs:
Hunched posture and piloerectiin were observed in some animals within 4 hours after dosing.Light-brown feces ware observed in all animals an day 2. No clinical signs were observed from day3 till to the end of study.
Body weight:
The body weights were increased during the study period.
Gross pathology:
No gross lesion was found in all animals.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test substance has a LD50 > 2000 mg/kg bw and is not classified via the oral route in rats.