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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to
Guideline:
other: Guidance on information requirements and chemical safety assessment Chapter R.7a: Endpoint specific guidance
Principles of method if other than guideline:
- Principle of test: the log Kow was calculated based on the solubility of the substance in octanol and in water.
GLP compliance:
no
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
- Batch N° 900501
Analytical method:
photometric method
Key result
Type:
log Pow
Partition coefficient:
> 7.54
Temp.:
22 °C
Remarks on result:
other: pH not determined

Solubility in octanol: 260 g/L

The solubility in water was zero, therefore the log Kow tends to the infinity. However, based on the limit of detection of the method used to determine the solubility in water a worst case concentration of 0.0075 mg/l is calculated.

log P = log (conc in oct / conc in water) = 7.54 and tends to the infinity

Conclusions:
The solubilities of the test item in octanol and in water were measured separately and then compared to each other (as advised in the R7a ECHA REACH Guideline) . The extrapolated log Kow value for Sepisol fast Blue 85219 was calculated to be 7.54.

Description of key information

The estimation of the log Kow is based on the ratio of the solubility of the substance in octanol and in water separately. The log Kow value was calculated to be between 7.54 and the infinity. Indeed, the hydrosolubility tends toward 0.

Therefore, the calculated log Kow value is not accurate and uncertain, but in a worst case scenario, a minimal value of 7.54 is selected

Key value for chemical safety assessment

Log Kow (Log Pow):
7.54
at the temperature of:
22 °C

Additional information