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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source only

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Chloroacetic acid, CAS No: 79-11-8
Author:
OECD SIDS
Year:
1996
Bibliographic source:
http://www.inc hem.org/doc uments/sids/s ids/79118.pdf
Reference Type:
publication
Title:
Fundamental and Applied Toxicology, 9, 469-479
Author:
Berardi, M.R. et al.,
Year:
1987
Bibliographic source:
Monochloroacetic acid toxicity in the mouse associated with blood-brain barrier damage.

Materials and methods

Principles of method if other than guideline:
Mice were exposed to test concentrations up to 800 mg chloracetic acid/kg bw by the oral route to evaluate the LD50.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroacetic acid
EC Number:
201-178-4
EC Name:
Chloroacetic acid
Cas Number:
79-11-8
Molecular formula:
C2H3ClO2
IUPAC Name:
chloroacetic acid
Details on test material:
- Name of test material (as cited in study report): Chloracetic acid
- Analytical purity: 99%

Test animals

Species:
mouse
Strain:
Swiss Webster
Sex:
male

Administration / exposure

Route of administration:
other: oral (no further information)
Doses:
up to 800 mg/kg bw

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
260 mg/kg bw
Based on:
test mat.
Other findings:
Some surviving mice exposed to concentrations around the LD50 developed front paw paralysis and brain damage. Single doses of 80, 118 or 174 mg/kg bw produced "little or no mortality".

Applicant's summary and conclusion