Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 26, 1992 - October 28, 1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
This study has been performed according to OECD 104 (1981), EU Method A.4 (1984) and according to GLP principles. But as the vapour pressure of the substance is below 1 Pa, the used method is considered to be not the most suitable method. Limited information available to verify the composition of the used test substance.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report Date:
1992

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
yes
Remarks:
as the vapour pressure of the substance is below 1 Pa, there are more suitable methods than the static method
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
yes
Remarks:
as the vapour pressure of the substance is below 1 Pa, there are more suitable methods than the static method
GLP compliance:
yes
Type of method:
static method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): KY-MA
- Physical state: Light yellow solid
- Storage condition of test material: At room temperature in the dark

Results and discussion

Vapour pressure
Temp.:
25 °C
Vapour pressure:
0.051 Pa

Any other information on results incl. tables

- The vapour pressure measurements were started at 38.89°C. The vapour pressure decreased with subsequent measurements, but this decrease was negligible after measurement 40. During measurement 52 the temperature of the thermostatic bath in which the sample vessel is immersed was lowered to 31.64°C and finally during measurement 68 to 24.80°C. During measurement 114 the experimental part of the study was finished.

- Results based on which the curve was plotted:

Serie

Measurements

Temperature [°C]

Mean vapour pressure, p [Pa]

Ln (p)

1

40-51

38.89

0.153

-1.88

2

55-67

31.64

0.084

-2.48

3

75-113

24.80

0.056

-2.88

- Fitting this data according to Clark & Glew gives a value of 0.0551 Pa (CV: 6%) for the vapour pressure at 25 degrees Celsius

- With a sensor temperature of 343 K the correction for thermal transpiration was determined to be (298/343)^0.5 = 0.932

- Resulting in the vapour pressure: 0.0551 x 0.932 = 0.051 Pa at 25 degrees Celsius

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the substance is 0.051 Pa (at 25 degrees Celsius), determined with the static method according to OECD 104 (1981), EU Method A.4 (1984) and according to GLP principles.