Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 21, 1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study has been performed according to EU Method A.1 (1989) and according to GLP principles. Limited information available to verify the composition of the used test substance.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report Date:
1992

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
(1989)
Deviations:
no
GLP compliance:
yes
Type of method:
thermal analysis
Remarks:
(differential scanning calorimetry (DSC))

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): KY-MA
- Physical state: Light yellow solid
- Storage condition of test material: At room temperature in the dark

Results and discussion

Melting / freezing point
Decomposition:
yes
Decomp. temp.:
>= 180 °C
Remarks on result:
other: The substance has no melting point. Evaporation, reaction and/or decomposition of the substance starts at 180°C.

Any other information on results incl. tables

Preliminary test

Two endothermic peaks, which partly overlap each other, were observed between about 180 and 330°C. At higher temperatures, around about 360°C possibly a small exothermic effect was detected. During the experiment the sample lost 7.99 mg (95%) of its mass and changed into a black powder.

Main study

- First run: this run was performed to investigate the run registered during the preliminary test. The endothermic effect started at about 190°C. The sample lost 4.95 mg (56%) of its mass during this run; it was changed into a yellow/brown powder.

- Second run: during this run, the endothermic effect which was observed in the 1st run could not be detected, which implies that it was caused by an irreversible process, e.g. evaporation, reaction and/or decomposition of (part of) the test substance. The second endothermic effect started at about 247°C. After this run, the sample appeared to be a dark brown powder; it had lost 3.50 mg (40%) of its mass.

- Third run: no endothermic heat effect was observed.; therefore also the second observed endothermic peak is considered to be caused by an irreversible process, e.g. evaporation, reaction and/or decomposition of (part of) the test substance. Between about 275 and 357°C a base-line shift was observed. It is not clear what process caused this shift. The sample lost 0.02 mg (0.2%) of its mass; the residue was a black powder.

Applicant's summary and conclusion

Conclusions:
In accordance with EU Method A.1 (1989) and according to GLP principles the melting point of the substance (a solid under ambient conditions) was determined using DSC. It was found that the substance has no melting point. Evaporation, reaction and/or decomposition of the substance starts at 180°C.