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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 August 2002 - 14 January 2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was conducted according to OECD and US EPA test guidelines, and in compliance with GLP; on this basis the result is considered reliable without restriction.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report Date:
2004

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Qualifier:
according to
Guideline:
EPA OPPTS 870.1300 (Acute inhalation toxicity)
GLP compliance:
yes (incl. certificate)
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2-Bromo-3,3,3-trifluoropropene (CAS 1514-82-5)
- Physical state: Colourless volatile liquid
- Analytical purity: ≥99.5%
- Lot/batch No.: KGA154-2B
- Storage condition of test material: Room temperature

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
nose only
Vehicle:
air
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
Group 1: Target 25,000 ppm, Analytical 26,580 ppm, Nominal 29,400 ppm
Group 4: Target 5,000 ppm, Analytical 5,173 ppm, Nominal 6,220 ppm
No. of animals per sex per dose:
5 males and 5 females per dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
11 726 ppm
Based on:
test mat.
95% CL:
9 054 - 15 186
Exp. duration:
4 h
Mortality:
26,580 ppm: 10/10 died
5,173 ppm: 0/10 died
Clinical signs:
other: During exposure, labored breathing or gasping was reported during the last hour of each exposure. Immediately following the exposures, clear or red nasal discharge, excessive salivation, labored breathing and mosit rales were observed. The severity and
Body weight:
All surviving animals gained weight (or did not lose weight) during both weeks of observation.
Gross pathology:
One or more rats from both exposure levels had red discoloration of the lungs. Fluid was present in the lungs of one male fromt he higher level exposure of 26,580 ppm. Microscopically, in the unscheduled deaths, the discoloration was due to vascular congestion which is commonly seen in rats not found dead or moribund rior to post mortem examination. The scattered red foci were agonal hemorrhages. All of the rats in the 26, 580 ppm group had bronchiolar lesions consisting of desquamated epithelium, bronchiolar/peribronchiolar acute/subacute inflammation and/or intraluminal debris; the severity of the findings ranged from slight to moderate. Alveolar/intralveolar macrophages (minimal to moderate) normally present in lungs, were most numerous in several of these rats. Other findings in the lungs ocurred sporadically and were not considered to be test substance related. these findings have been seen in rats of this strain and age used in similar studies conducted at this facility.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The 4-hr acute inhalation toxicity in rats was 11,726 ppm.