Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

The test article was evaluated in an exploratory microbial mutation assay over a concentration range of 100 to 5000µg / plate Salmonella typhimuriumtest strains TA1535, TA97a, TA98, and TA100 and Escherichia coli test strain WP2 uvrA pKM101 were used, with and without metabolic activation (S-9 liver extract). The results indicated that the test article, up to the highest tested concentration, did not produce any 2 -fold or greater increases in revertants relative to the solvent control in any of the test strains, either with or without metabolic activation.


Short description of key information:
In an Ames study, the results indicated that the test article did not produce any 2-fold or greater increases in revertants in any of the test strains, either with or without metabolic activation.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The substance does not meet classification criteria under EU Directive 67/548/EEC for genetic toxicity.

The substance does not meet classification criteria under Regulation (EC) No 1272/2008 for genetic toxicity.