Registration Dossier

Administrative data

Description of key information

The LD50 was greater than 300 mg/kg bw, but less than 2000 mg/kg bw in rats. Accordingly, the test item was considered to be in Acute Toxic 
Category 4.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
300 mg/kg bw

Additional information

At a single oral dose of 2000 mg/kg bw, all three animals died. Ante-mortem clinical signs included convulsions, negative righting reflex, brown staining of the mouth/nose area and rigid muscle tone. All six animals survived a single 300 mg/kg bw dose. At the 300 mg/kg bw dose, the only clinical signs were brown staining of the nose/mouth area in one animal.

Justification for classification or non-classification

The substance meets classification criteria under EU Directive 67/548/EEC for acute oral toxicity.

The substance meets classification criteria under Regulation (EC) No 1272/2008 for Acute Toxicity - Oral, Category 4.