Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
Reaction mass of disodium 2-{[2-(acylamino)-4-({4-chloro-6-[(3-sulfonatophenyl)amino]-1,3,5-triazin-2-yl}amino)phenyl]diazenyl}-(vinylsulfonyl)benzenesulfonate and trisodium 2-{[2-(acylamino)-4-({4-chloro-6-[(3-sulfonatophenyl)amino]-1,3,5-triazin-2-yl}amino)phenyl]diazenyl}-{[2-(sulfonatooxy)ethyl]sulfonyl}benzenesulfonate
EC number: - | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 April 2013 to 8 May 2013
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Reaction mass of disodium 2-{[2-(carbamoylamino)-4-({4-chloro-6-[(3-sulfonatophenyl)amino]-1,3,5-triazin-2-yl}amino)phenyl]diazenyl}-5-(vinylsulfonyl)benzenesulfonate and trisodium 2-{[2-(carbamoylamino)-4-({4-chloro-6-[(3-sulfonatophenyl)amino]-1,3,5-triazin-2-yl}amino)phenyl]diazenyl}-5-{[2-(sulfonatooxy)ethyl]sulfonyl}benzenesulfonate
- IUPAC Name:
- Reaction mass of disodium 2-{[2-(carbamoylamino)-4-({4-chloro-6-[(3-sulfonatophenyl)amino]-1,3,5-triazin-2-yl}amino)phenyl]diazenyl}-5-(vinylsulfonyl)benzenesulfonate and trisodium 2-{[2-(carbamoylamino)-4-({4-chloro-6-[(3-sulfonatophenyl)amino]-1,3,5-triazin-2-yl}amino)phenyl]diazenyl}-5-{[2-(sulfonatooxy)ethyl]sulfonyl}benzenesulfonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA 1535, TA 97a, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 hamster liver and/or rat liver
- Test concentrations with justification for top dose:
- 1. experiment: 4999, 1500, 500, 150, 50 microg/plate
2. experiment: 4999, 2500, 1250, 626, 313 microg/plate - Vehicle / solvent:
- deionized water
Controls
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- sodium azide
- benzo(a)pyrene
- congo red
- other: 4-Nitro-1,2-phenylene diamine; 2-Amino-anthracene
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA97a, TA 98, TA100, TA102, TA1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
The test item is considered as not mutagenic.
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