Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The sensitisation potential of D6N-acetate was assessed using a method based on the maximisation test described by Magnusson and Kligman (1970). The study involved the treatment of guinea pigs using two procedures: the potential induction of an immune response and a challenge by assessing the degree of erythema.

Following challenge of previously induced guinea pigs with a 92% or a 75% w/v preparation of the test substance in corn oil, no erthematous response was seen on any of the test or control animals. A positive control study using hexylcinnamaldehyde demonstrated the sensitivity of the test system.

D6N-acetate and D6N, by read across, are not skin sensitisers under the conditions of the test.


Migrated from Short description of key information:
Based on read-across from similar substance, D6N is not sensitising.

Justification for classification or non-classification

Based on read-across from similar substance, D6N is not sensitising.