Registration Dossier
Registration Dossier
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EC number: 939-526-9 | CAS number: 90506-73-3
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The substance has a low potential for bioaccumulation.
Key value for chemical safety assessment
Additional information
According to Reach regulation, Annex IX, Column 2 the study does not need to be conducted as the substance has a low potential for bioaccumulation (log Kow =2.5).
However, data on bioaccumulation are available for the read-across source substance Dibutyl phosphate. The read-across approach is justified based on structural similarity, similar log Kow and similar metabolism.
The log Kow of Dibutyl phosphate predicted by ACD/Labs and EPISuite are 2.451 and 2.29, respectively (http://www.chemspider.com/Chemical-Structure.7593.html); the log Kow of the registered substance is 2.5.
Phosphoric acid alkyl esters are hydrolysed unspecifically to Phosphoric acid and the respective alcohol by phosphatases, e.g. Acid phosphatase or Alkaline phosphatase. Both enzymes are found in most organisms from bacteria to human. The difference in chain length is not considered relevant for the assessment of bioaccumulation potential. After hydrolysis, the respective alcohol moieties are oxidised to the corresponding carboxylic acid which will enter the normal carboxylic acid metabilism.
Phosphate as such is not metabolised. It “is an essential dietary constituent, involved in numerous physiological processes, such as the cell’s energy cycle (high-energy pyrophosphate bonds in adenosine triphosphate [ATP]), regulation of the whole body acid-base balance, as component of the cell structure (as phospholipids) and of nucleotides and nucleic acids in DNA and RNA, in cell regulation and signalling by phosphorylation of catalytic proteins and as second messenger (cAMP).” (EFSA, 2005; available via internet:http://www.efsa.europa.eu/en/efsajournal/doc/233.pdf).
Bioaccumulation of the read-across substance Dibutyl phosphate was tested according to OECD 305C (1981) and Japanese "Method for Testing the Degree of Accumulation of Chemical Substances in Fish Body" stipulated in the "Testing Methods for New Chemical Substances" (July 13, 1974) with the fish Cyprinus carpio. Two concentrations (2 mg/L, 0.2 mg/L) were tested for 6 weeks in a flow through method. The BCF was calculated as quotient of water concentration and concentration in whole fish (homogenised).
The BCF for Dibutyl phosphate was determined to be ≤0.7 (water concentration 2 mg/L) resp. ≤6.9 (water concentration 0.2 mg/L).
A preceeding semistatic acute toxicity test with the fish Oryzias latipes for 48 h resulted in a 48h LC50 of > 250 mg/L. The substance was stable under storage and test conditions.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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