Registration Dossier
Registration Dossier
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EC number: 200-826-3 | CAS number: 74-97-5
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Type of information:
- other: Publication
- Adequacy of study:
- supporting study
- Study period:
- 1966
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Chronic Inhalation Toxicity of CHLOROBROMOMETHANE
- Author:
- MacEwen, James D.; McNerney, James M.; Vernot, Edmond H.; Harper, David T.
- Year:
- 1 966
- Bibliographic source:
- J. Occupational Med. (1966), 8(5), 251-6
Materials and methods
- GLP compliance:
- not specified
Test animals
- Species:
- dog
- Strain:
- Beagle
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- Daily inhalation exposure of. CH2ClBr 30 hrs. weekly for 6 months at levels of 500 and 1000 ppm.
- Duration of treatment / exposure:
- 30 hrs. weekly for 6 months
- Frequency of treatment:
- Daily
Results and discussion
Results of examinations
- Details on results:
- Serum bromide ion concentration in dogs and rats were above 95mg% in the exposed animals.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- It may concluded that the current ACGIH threshold limit value of 200 ppm for CHLOROBROMOMETHANE.
This limit is a satisfactory working level for chronic daily exposure.
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