Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-197-3 | CAS number: 104-38-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- O.5 g of substance was applied to the skin of 5 guinea pigs for 24 hours under an occlusive dressing.
- GLP compliance:
- no
- Remarks:
- However was subject to Quality Assurance
Test material
- Reference substance name:
- 2,2'-p-phenylenedioxydiethanol
- EC Number:
- 203-197-3
- EC Name:
- 2,2'-p-phenylenedioxydiethanol
- Cas Number:
- 104-38-1
- Molecular formula:
- C10H14O4
- IUPAC Name:
- 2,2'-[1,4-phenylenebis(oxy)]diethanol
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- other: Cr1:(HA) BR Hartley
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- Moistened with water
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 15 days
- Number of animals:
- 5 Females
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24/48 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 15 days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Irritant / corrosive response data:
- No signs of irritation were observed over the 15 day observation period
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria (Reg 1272/2008) are not met
- Conclusions:
- HQEE was not irritating to guinea pig skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
