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EC number: 259-515-6
CAS number: 55184-72-0
1.Rabbit eye irritation
Rabbit Number, Value
the readings made at 24, 48 and 72 hours, there was:
discernible opacity or ulceration of the cornea other than a slight
dulling of the normal luster.
inflammation of the iris other than slight deepening of the folds, or
slight circumcorneal injection.
deep-crimson red appearance of the conjunctivae, with individual vessels
not easily discernible.
obvious swelling of the conjunctivae, excluding cornea and iris, with
partial eversion of the lids.
destruction or irreversible change of any tissue in 24 hours, or less.
0.1 g Butanedioic acid, sulfo-, 1,4 -ditridecyl
ester, sodium salt (70% active) was introduced into the conjunctival sac
of 6 rabbits. Scoring according to Draize et al. (1944) demonstrated a
mean cornea score of 14/80, a mean
iris score of 1/10 and a mean conjuctiva score of 6.3/20. At
the readings made at 24, 48 and 72 hours, there was discernible
opacity or ulceration of the cornea other than a slight dulling of the
normal luster,adiffuse, deep-crimson
red appearance of the conjunctivae, with individual vessels not easily
discernible, and an obvious swelling
of the conjunctivae, excluding cornea and iris, with partial eversion of
the lids. It was concluded that the test item containing
70% active ingredient produces irritation of rabbit eyes. Therefore, precaution
should be observed to avoid its introduction into or near the eyes.
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