Registration Dossier
Registration Dossier
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EC number: 939-607-9 | CAS number: 1474044-65-9
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
In a reliable guideline study, the read-across substance C12-18 TMAC was considered to be hydrolytically stable. Therefore based on the read-across approach, C12-14 ADMAES is also expected to be hydrolytically stable.
Key value for chemical safety assessment
Additional information
In a guideline study, the hydrolysis rate of the read-across substance C12-18 TMAC as a function of pH was determined. The study was conducted under dark conditions using three buffer solutions and one unbuffered solution (pH of approximately 6.2) at 25±1˚C: pH 5 [acetic acid/sodium acetate], pH 7 [tris (hydroxymethyl) - amino methane/HCl], pH 9 [boric acid/sodium borate] and a solution containing deionized water. The buffer solutions were spiked at approximately 100 ppm levels (based on 100% activity of the test substance). Each of the four solutions was sampled on Day 0, 5, 12, 19, 26 and 33. The pH of each solution remained within 0.1 pH unit of the starting value throughout the 33 day sampling period. Each buffer solution was analysed in duplicate. Under the conditions of the study, the substance was considered to be hydrolytically stable. More than 90% of the test substance remained intact at all aqueous pH systems throughout the study (Szajer G, 1989).
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