Anthraquinone

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

sub-chronic toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: No data to assess the validity of the results.

Data source

Reference

Reference Type:

publication

Title:

Materialy k obosnovaniju predelno dopustimoj koncentraciji antrachinona v vozduche rabocej zony

Author:

Volodchenko VA et al.

Year:

1971

Bibliographic source:

Gigiena Truda Prof. Zabol. 15(2), 58-59

Materials and methods

Principles of method if other than guideline:

Rats were exposed to the test substance via inhalation during 5-6 h per day with a exposure period of 4 months

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Anthraquinone

EC Number:

201-549-0

EC Name:

Anthraquinone

Cas Number:

84-65-1

Molecular formula:

C14H8O2

IUPAC Name:

9,10-dihydroanthracene-9,10-dione

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

not specified

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

5-6 h/day during 4 months

Frequency of treatment:

Daily

Doses / concentrations

Remarks:

Doses / Concentrations:
0.0052 or 0.0122 mg/L
Basis:
no data

No. of animals per sex per dose:

No data

Control animals:

not specified

Details on study design:

- Post-exposure observation period: 1 month

Results and discussion

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

No toxic effects were observed at the dose 0.0052 mg/L.

At the dose 0.0122 mg/L the following effects were observed: body weight loss, changes of the bloodpicture (lowered level of haemoglobin, erythrocytopenia, relative reticulopenia); histopathological findings in the lungs: emphysema, atelectasis, cellular proliferation, in particular perivascular hyperemia of the capillaries and exsudation in the alveolar lumen (blood picture normalised during the experimental period, changes of the lung regenerated within the first month after termination of the experiment.

Applicant's summary and conclusion

Conclusions:

At the dose 0.0122 mg/L the following effects were observed: body weight loss, changes of the bloodpicture (lowered level of haemoglobin, erythrocytopenia, relative reticulopenia); histopathological findings in the lungs: emphysema, atelectasis, cellular proliferation, in particular perivascular hyperemia of the capillaries and exsudation in the alveolar lumen (blood picture normalised during the experimental period, changes of the lung regenerated within the first month after termination of the experiment).

Executive summary:

Rats were exposed to the test substance via inhalation during 5-6 h per day with a exposure period of 4 months. No toxic effects were observed at the dose 0.0052 mg/L. At the dose 0.0122 mg/L the following effects were observed: body weight loss, changes of the bloodpicture (lowered level of haemoglobin, erythrocytopenia, relative reticulopenia); histopathological findings in the lungs: emphysema, atelectasis, cellular proliferation, in particular perivascular hyperemia of the capillaries and exsudation in the alveolar lumen (blood picture normalised during the experimental period, changes of the lung regenerated within the first month after termination of the experiment).