Registration Dossier
Registration Dossier
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EC number: 202-669-6 | CAS number: 98-44-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- RTECS Number: CZ9250000
- Author:
- Organicke Latky," Marhold, J., Prague,
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); 85JCAE "Prehled Prumyslove Toxikologie; Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1052,1986
- Reference Type:
- review article or handbook
- Title:
- DPIM : AIE000
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials): Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia.: , 1972, 182.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Standard Draize test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-aminobenzene-1, 4-disulphonic acid
- IUPAC Name:
- 2-aminobenzene-1, 4-disulphonic acid
- Reference substance name:
- 2-aminobenzene-1,4-disulphonic acid
- EC Number:
- 202-669-6
- EC Name:
- 2-aminobenzene-1,4-disulphonic acid
- Cas Number:
- 98-44-2
- Molecular formula:
- C6H7NO6S2
- IUPAC Name:
- 2-aminobenzene-1,4-disulphonic acid
- Details on test material:
- - Name of test material: 2-aminobenzene-1, 4-disulphonic acid
- Molecular formula: C6H7NO6S2
- Molecular weight: 253.25
- Substance type: Organic
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- 24 H
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24H
- Score:
- 100
- Max. score:
- 100
- Reversibility:
- not specified
- Remarks on result:
- other: Moderately irritating
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 2-aminobenzene-1, 4-disulphonic acid is moderately irritating to rabbit's eye at dose concentration of 100 mg/24H by Standard Draize test.
- Executive summary:
2-aminobenzene-1, 4-disulphonic acid is moderately irritating to rabbit's eye at dose concentration of 100 mg/24H by Standard Draize test and so the substance will qualify for classification in category 2 for eye irritation.
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