Cobalt, borate propionate complexes

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2009-03-31 to 2009-05-21

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

, 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

, 2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

signed 2008-11-12

Type of method:

flask method

Water solubility:

33 258.2 mg/L

Temp.:

20 °C

Remarks on result:

other: Baed on a measured concentration of 12172.5 mg Co/L

Water solubility:

34 661.9 mg/L

Temp.:

37 °C

Remarks on result:

other: Baed on a measured concentration of 12686.3 mg Co/L

Details on results:

The water solubility of cobalt boron propionate at 20 °C (after 72 hours of shaking) was determined to be 33258.2 mg/L and at 37 °C (after 72 hours of shaking) 34661.9 mg/L. The measured results differ by less than 7%. Therefore, the study is considered to be valid.

From the results obtained by the Perkin-Elmer software the concentration of Cobalt in the analyzed solutions was calculated by the following equations (1) and (2):

C1 = x – Blank        (1)

C2 = C1 · f              (2)

Where C1 = Concentration of cobalt in the test item solution after saturation [μg/mL]

x = Measured concentration of cobalt in the sample solution [μg/mL]

Blank = Measured concentration of cobalt in the blank solution [μg/mL]

C2 = Concentration of cobalt in the test item solution before dilution [μg/mL]

f = Dilution factor

From the concentration of Cobalt the water solubility of the test item was calculated by the following equation (3):

C₃ = (C₂ *100) / C_Co       (3)

Where

C₃ = Water solubility of the test [μg/mL]

C₂ = Result of equation (2)

100 = Calculation factor [%]

C_Co = Concentration of cobalt in the test item as given by the Sponsor (here: 36.6%)

Conclusions:

Interpretation of results: very soluble (> 10000 mg/L)
During this study the water solubility of the test item at 20 °C and at 37 °C were determined using the flask method and was found to be 33258.2 mg/L at 20 °C (based on a measured concentration of 12172.5 mg Co/L) and 34661.9 mg/L at 37 °C (based on a measured concentration of 12686.3 mg Co/L ).

Description of key information

Water solubility of cobalt, borate propionate complexes (flask method, guideline study results): 33258.2 mg/L at 20 °C and 34661.9 mg/L at 37 °C.

Key value for chemical safety assessment

Water solubility:

33 258.2 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of cobalt, borate propionate complexes was determined according to OECD guideline 105 with the flask method. During this study the water solubility of the test item was found to be 33258.2 mg/L at 20 °C (after 72 hours of shaking) based on a measured concentration of 12172.5 mg Co/L and 34661.9 mg/L at 37 °C (after 72 hours of shaking) based on a measured concentration of 12686.3 mg Co/L.