Registration Dossier
Registration Dossier
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EC number: 216-223-3 | CAS number: 1530-32-1
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
- Principles of method if other than guideline:
- The data used for the toxicokinetic assessment are derived from measured physical chemical endpoints as well as from a single dose oral and dermaltoxicity study and a 28-day repeated dose toxicity study.
Test material
- Reference substance name:
- Ethyltriphenylfosfonium bromide
- EC Number:
- 216-223-3
- EC Name:
- Ethyltriphenylfosfonium bromide
- Cas Number:
- 1530-32-1
- Molecular formula:
- C20H20P.Br
- IUPAC Name:
- bromo(ethyl)triphenylphosphorane
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Based on its physical/chemical properties, absorption factors for TEP are derived to be 50% (oral), 100% (inhalation) and 100% (dermal). The
dermal absorption is considered to be overestimated as it is generally accepted that dermal absorption is lower compared to oral absorption.
Absorbed TEP might be metabolized and is expected to distribute widely throughout the body; TEP is not expected to accumulate or to be retainedin the body and excretion will be mainly via urine.
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