Registration Dossier
Registration Dossier
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EC number: 216-223-3 | CAS number: 1530-32-1
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Estimation Programs Interface Suite (2018) was run to predict the biodegradation potential of the test chemical in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that test chemical is expected to be not readily biodegradable.
Biodegradation in water and sediment
Estimation Programs Interface (2018) prediction model was run to predict the half-life in water and sediment for the test compound. If released in to the environment, 2.76% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical in sediment is estimated to be 337.5 days (8100 hrs). Based on this half-life value, it indicates that test chemical is persistent in sediment.
Biodegradation in soil
The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (2018). If released into the environment, 36.2% of th chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Predicted data and various experimental studies of the test chemical were reviewed for the biodegradation end point which are summarized as below:
In a prediction using the Estimation Programs Interface Suite (2018), the biodegradation potential of the test chemical in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that test chemical is expected to be not readily biodegradable.
In a supporting weight of evidence study from secondary source (2006) for the test item,biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test chemical. The study was performed according to equivalent or similar OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test) under aerobic conditions. Peptone was used as a co-substrate. Industrial sludge was used as a test inoculums for the study. Initial test chemical concentration used for the study was 200 mg/l. No inhibition of bacterial growth by test chemical was observed in a pre-test. The percentage degradation of test chemical was determined to be < 20% by O2 consumption in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
For the test chemical, biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test chemical (J-CHECK, 2018). Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test chemical was determined to be 0% by O2 consumption, BOD, TOC removal, Test material analysis and HPLC parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
In a supporting weight of evidence study, biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test chemical (IUCLID dataset, 2000). The study was performed according to other guideline EEC Directive 79–831 Annex V under aerobic conditions. Activated sludge, domestic was used as a test inoculums for the study. The percentage degradation of test chemical was determined to be <10% by Test material analysis parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
Another biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test chemical (secondary source, 2000). The study was performed according to OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test) under aerobic conditions. Municipal activated sludge was used as a test inoculums for the study. The percentage degradation of test chemical was determined to be < 20% by O2 consumption in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
On the basis of above results for test chemical, it can be concluded that the test chemical can be expected to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (2018) prediction model was run to predict the half-life in water and sediment for the test compound. If released in to the environment, 2.76% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical in sediment is estimated to be 337.5 days (8100 hrs). Based on this half-life value, it indicates that test chemical is persistent in sediment.
Biodegradation in soil
The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (2018). If released into the environment, 36.2% of th chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test chemical can be considered to be not readily biodegradable in nature.
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