Registration Dossier

Physical & Chemical properties

Dissociation constant

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Description of key information

Substance: not relevant
Hydrolysis product: approximately 12, based on read-across from dimethylsilanediol

Key value for chemical safety assessment

Additional information

The requirement to test the substance for dissociation constant is waived because the substance has no dissociable groups. There are no reliable measured data for the dissociation constant of (3-chloropropyl)methylsilanediol. The typical dissociation constants for the hydroxyl protons of silanediols are available from studies in other silanediols. It is appropriate to read-across dissociation constant data for (3-chloropropyl)methylsilanediol from dimethylsilanediol. This suggests that silanols are not expected to undergo significant dissociation within the range of pH relevant in the environment or in vivo. Dimethylsilanediol has a measured first dissociation constant ca. 11.9 reported in secondary literature. Additional information is given in a supporting report (PFA, 2013b) attached in Section 13 of the REACH technical dossier.