3-methoxybutyl acetate

Repeated dose toxicity: other routes

Administrative data

Endpoint:

short-term repeated dose toxicity: other route

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only short summary of proprietary study available, contributing to weight of evidence.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1930

Materials and methods

Principles of method if other than guideline:

A guinea pigs was injected subcutaneously with a 10% solution of 3-methoxybutyl acetate in oil for up to 6 days. Single doses were also given to another guinea pig and to rats (see 7.5.2).

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-methoxybutyl acetate

EC Number:

224-644-9

EC Name:

3-methoxybutyl acetate

Cas Number:

4435-53-4

Molecular formula:

C7H14O3

IUPAC Name:

3-methoxybutyl acetate

Constituent 2

Reference substance name:

4435-43-3

IUPAC Name:

4435-43-3

Constituent 3

Reference substance name:

butoxyl

IUPAC Name:

butoxyl

Details on test material:

No data

Test animals

Species:

guinea pig

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No details given

Administration / exposure

Route of administration:

subcutaneous

Vehicle:

other: oil

Details on exposure:

A 10% solution of 3-methoxybutyl acetate in oil was injected subcutaneously to 1 guinea pig, at a dose of 0.1 g/kg, on 6 consecutive days.

Analytical verification of doses or concentrations:

no

Duration of treatment / exposure:

6 days

Frequency of treatment:

Daily

Doses / concentrations

Remarks:

Doses / Concentrations:
0.1 g/kg

No. of animals per sex per dose:

1

Control animals:

no

Details on study design:

No data

Results and discussion

Results of examinations

Clinical signs:

no effects observed

Mortality:

no mortality observed

Body weight and weight changes:

not specified

Food consumption and compound intake (if feeding study):

not specified

Food efficiency:

not specified

Water consumption and compound intake (if drinking water study):

not specified

Ophthalmological findings:

not specified

Haematological findings:

not specified

Clinical biochemistry findings:

not specified

Urinalysis findings:

no effects observed

Behaviour (functional findings):

not specified

Organ weight findings including organ / body weight ratios:

not specified

Gross pathological findings:

not specified

Histopathological findings: non-neoplastic:

not specified

Histopathological findings: neoplastic:

not specified

Details on results:

There were no adverse symptoms and no abnormalities were found in the urine. No other details provided in translation document.

Effect levels

Dose descriptor:

NOAEL

Effect level:

100 mg/kg bw/day

Sex:

not specified

Basis for effect level:

other: No adverse clinical signs were seen in guinea pigs after 6 daily injections of 0.1 g/kg.

Target system / organ toxicity

Critical effects observed:

not specified

Applicant's summary and conclusion

Conclusions:

Subcutaneous injection of a 10% solution of 3-methoxybutyl acetate in oil did not cause any adverse effects to guinea pigs at a dose of 100 mg/kg/day for up to 6 days.

Executive summary:

A 10% solution of 3 -methoxybutyl acetate in oil was injected subcutaneously to a guinea pig at a dose of 100 mg/kg for 6 consecutive days. There were no adverse clinical signs and no abnormal findings in the urine. 3 -Methoxybutyl acetate, as a 10% solution in oil, was of low toxicity to guinea pigs by the subcutaneous route at a dose level of 100 mg/kg/day.