Registration Dossier
Registration Dossier
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EC number: 200-018-0 | CAS number: 50-21-5
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Company data with limited reporting
- Principles of method if other than guideline:
- Making of a saturated solution of lactic acid (solid) in various solvents, and determining the concentration dissolved lactic acid after a set period of time.
- GLP compliance:
- no
- Key result
- Medium:
- methanol
- Solubility:
- 78.6 other: % w/w
- Temp.:
- 20 °C
- Key result
- Medium:
- ethanol
- Solubility:
- 70.9 other: % w/w
- Temp.:
- 20 °C
- Key result
- Medium:
- other: n-propanol
- Solubility:
- 62.4 other: % w/w
- Temp.:
- 20 °C
- Key result
- Medium:
- isopropanol
- Solubility:
- 63.4 other: % w/w
- Temp.:
- 20 °C
- Medium:
- n-butanol
- Solubility:
- 54.5 other: % w/w
- Temp.:
- 20 °C
- Medium:
- other: 2-ethylhexanol
- Solubility:
- 29 other: % w/w
- Temp.:
- 20 °C
- Medium:
- other: hexane
- Solubility:
- 0.005 other: % w/w
- Temp.:
- 20 °C
- Medium:
- toluene
- Solubility:
- 0.11 other: % w/w
- Temp.:
- 20 °C
- Medium:
- diethyl ether
- Solubility:
- 38.7
- Temp.:
- 20 °C
- Medium:
- other: tetrahydrofuran
- Solubility:
- 65.1 other: % w/w
- Temp.:
- 20 °C
- Test substance stable:
- yes
- Conclusions:
- Lactic acid is soluble in most polar solvents, but sparingly soluble to insoluble in nonpolar solvents like hexane and toluene.
- Executive summary:
The objective of this piece of research was to determine the solubility of lactic add (crystals) in a number of common organic solvents ·and Purae products. With the results the best solvent(s) could be chosen to wash lactic acid crystals. Another objective was to increase the basic knowledge on lactic acid. Results were obtained by stirring dry lactic acid crystals at a certain temperature in a solvent. After 0.75-1 hour a sample was taken and analyzed on lactic acid (free acidity). The results are for pure monomeric lactic acid, therefore the solubility for lactic acid containing oligomers and/or water can be different.
Lactic acid is soluble in most polar solvents, but sparingly soluble to insoluble in nonpolar solvents like hexane and toluene.
Reference
Description of key information
Lactic acid is soluble in most polar solvents, but sparingly soluble to insoluble in nonpolar solvents like hexane and toluene.
Key value for chemical safety assessment
Additional information
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