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Additional information

Investigations for the mutagenic potential of CCP-V2-1 were performed using Salmonella typhimurium tester strains TA 98, TA 100, TA 1535 and TA 1537, and Escherichia coli WP2 uvrA. The plate incorporation test with and without addition of liver S9 mix from Aroclor 1254 -pretreated rats was used. With and without addition of S9 mix as the external metabolizing system, CCP-V2-1 was not mutagenic under the experimental conditions described.

CCP-V2-1 was assayed for its ability to induce mutations at th TK locus (5-trifluorothymidine resistance) in L5178Y mouse lymphoma cells using a fluctuation protocol. The test material was non-mutagenic in this test system under conditions where the positive controls exerted potent mutagenic effects.

Overall, we can conclude that CCP-V2-1 does not provide evidence of mutagenic toxicitity in vitro with and without metabolic activation.


Short description of key information:
The genetic toxicity of CCP-V2-1 was studied in two different in vitro assays including the bacterial reverse mutation assay and in mammalian test systems. CCP-V2-1 did not show mutagenic potential in vitro.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification