Registration Dossier
Registration Dossier
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EC number: 424-190-3 | CAS number: 105641-66-5 DIAZO ER 1273
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06/15/1992 to 06/19/1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1984
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- 1884
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were taken at 0 and 24 hours from the first and thrird preparation of water.
The substance undergoes fast hydrolysis i water which is complete aber 2 hours. Th reaction product was determined. - Vehicle:
- no
- Details on test solutions:
- The fish were transferred each 24 h to new test chambers.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Source: Dept. for Toxycology, Hoechst AG
Day of birth: 09/22/1991
Acclimatization: 14 days - Test type:
- semi-static
- Water media type:
- freshwater
- Remarks:
- reconstituted water acc. to ISO/DIS 7346/1
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Test temperature:
- 22+/- 1 °C
- pH:
- 7.6-8.5
- Dissolved oxygen:
- 7.0-9.6 mg/L
- Nominal and measured concentrations:
- 500 mg/L (measured 242 and 208 mg/L, 41-49 %)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
At study start hypoactivity as observed. Later in the study, the test material did not cause any effect and no mortality was observed during this study.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 (96 h) of the test material exceeds 500 mg/L, which is above the water solubility limit of the test item.
Reference
Description of key information
The EC50 (96 h) of the test material exceeds 500 mg/L, which is above the water solubility limit of the test item.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 500 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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