Registration Dossier
Registration Dossier
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EC number: 448-250-3 | CAS number: -
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 66.67 mg/kg food
- Assessment factor:
- 300
Additional information
Conclusion on classification
Classification related key information
Water solubility: < 0.02 mg/L (OECD 105)
Biodegradation in water: screening tests: 4% (CO2 evolution) after 29 days (OECD 301B)
Log Pow: 8.4
Acute aquatic toxicity
- to fish: No effects were observed in the range of the water solubility of the test substance (< 0.02 mg/L), LC50 (96 h) > 0.014 mg/L, Cyprinus carpio (OECD 203, EU Method C.1)
- to aquatic invertebrates: No effects were observed in the range of the water solubility of the test substance (< 0.02 mg/L), EC50 (48 h) > 0.017 mg/L, Daphnia magna (OECD 202, EU Method C.2)
- to algae: No effects were observed in the range of the water solubility of the test substance (< 0.02 mg/L), Pseudokirchneriella subcapitata (OECD 201, EU Method C.3)
Chronic aquatic toxicity:
- to fish: not available
- to aquatic invertebrates: not available
- to algae: No effects were observed in the range of the water solubility of the test substance (< 0.02 mg/L), Pseudokirchneriella subcapitata (OECD 201, EU Method C.3).
Classification justification according to CLP
2 -Hexyl-2 '-hydroxy-5 'methyldecananilide (AF-654) is poorly soluble in water and no toxicity to aquatic organisms (fish, aquatic invertebrates, algae) was observed up to its water solubility limit (< 0.02 mg/L). Nevertheless, since the substance is not rapidly biodegradable and exhibits a potential for bioaccumulation (log Pow 8.4), AF-654 is classified as environmental hazard Chronic Cat. 4 according to the regulation (EC) No. 1272/2008 (CLP) and the Regulation (EU) No. 286/2011 (2nd ATP).
Classification justification according to DSD
For fish, aquatic invertebrates and algae, no toxic effects were observed up to the water solubility limit of 2 -Hexyl-2 '-hydroxy-5 'methyldecananilide (AF-654) (<0.02 mg/L).
Based on the data above, the substance is considered to have a potential for bioaccumulation and is not rapidly degradable. Therefore, AF-654 is classified as environmental hazard R53 according to the Directive 67/548/EEC (DSD).
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