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EC number: 953-513-5
CAS number: -
INDIVIDUAL SCORES FOR OCULAR IRRITATION
Rabbit No.: 3401 (Female)
Rabbit No.: 3402 (Female)
Rabbit No.: 3403 (Female)
A primary eye irritation test was conducted with rabbits to determine the potential for Dihydronepetalactone to produce irritation from a single instillation via the ocular route. One-tenth of a milliliter of the test substance was instilled into the right eye of three healthy rabbits. The left eye remained untreated and served as a control. Ocular irritation was evaluated by the Draize method of scoring.Within 24 hours after test substance instillation, two treated eyes exhibited corneal opacity and ‘positive’ conjunctivitis. There was no iritis observed in any treated eye during this study. The overall incidence and severity of irritation decreased gradually with time. Positive irritation cleared from the two treated eyes by Day 4. All animals were free of ocular irritation by Day 7 (study termination).
The Maximum Mean Total Score of Dihydronepetalactone is 14.7. Under the conditions of this study, Dihydronepetalactone is classified as mildly irritating to the eye.
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