Registration Dossier
Registration Dossier
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EC number: 234-207-4 | CAS number: 10595-80-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1957
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
- Principles of method if other than guideline:
- Rabbits received the test material undiluted and as 10% aqueous solution onto the eye
- GLP compliance:
- no
- Remarks:
- GLP regulations were not in place at the time of this study.
Test material
- Reference substance name:
- Sulphoethyl methacrylate
- EC Number:
- 234-207-4
- EC Name:
- Sulphoethyl methacrylate
- Cas Number:
- 10595-80-9
- Molecular formula:
- C6H10O5S
- IUPAC Name:
- sulphoethyl methacrylate
- Test material form:
- liquid: viscous
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- not specified
- Duration of treatment / exposure:
- not specified
- Observation period (in vivo):
- not specified
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- other: corrosion
- Basis:
- mean
- Time point:
- other: not specified
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- The test substance caused extensive pain, conjunctivitis and corneal damage, resulting in permanent loss of vision on both eyes
- Other effects:
- 10% aqueous solution: slight pain, conjunctivitis with transient corneal damage essentially subsided in 24 h. Eyes normal after one week.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Undiluted 2-SEM caused irreversible eye damage, whereas a 10% aqueous solution caused reversible eye irritation.
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