Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-333-0 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (positive)
Genetic toxicity in vivo
Link to relevant study records
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Remarks:
- Target chemical
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- read-across
- Vehicle controls validity:
- valid
- Remarks:
- read-across
- Negative controls validity:
- valid
- Remarks:
- read-across
- Positive controls validity:
- valid
- Remarks:
- read-across
- Additional information on results:
- On the basis of the “Read-Across Assesment Framework (RAAF)-consideration on multi-constituent substances and UVCBs” (issued by the ECHA, March 2017) we can say that
the main molecules of the target substance are in the same “pool” like the main molecules of the tested substances.
The functional groups are the same of the compared molecules and the concentration range show quite convincing overlap.
The OECD ToolBox was used to profile this structure and the test structures for structural similarity and organic functional groups to demonstrate similarity. The chemical elements found in the comparator structure (hydrogen, oxygen, carbon and chlorine) are similar in composition and arrangement to those found in the test structure. The molecular weight is also in a similar range to that observed in the test structures. - Conclusions:
- The structural similarities between the source and the target substances presented above support the read-across hypothesis. Adequate, reliable and available scientific information indicates that the source and target substances have similar toxicity profiles.
Therefore, based on the considerations above, it can be concluded that the results of the In vivo mutagenicity studies with the source substances is likely to predict the properties of the target substance and are considered as adequate to fulfil the information requirement of Annex VIII. - Executive summary:
Read across results from source substances, that the target substance is considered to be negative for endpoint in vivo mutagenicity.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
Based on read-across in vivo studies, it is not classifed as mutagen.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
