4-(2-chlorophenyl)-N-cyclohexyl-N-ethyl-5-oxo-4,5-dihydro-1H-tetrazole-1-carboxamide

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

February 22, 1995 - May 6,1996

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

GLP compliance:

yes

Type of method:

gas saturation method

Temp.:

20 °C

Vapour pressure:

0 hPa

Remarks on result:

other: 5x10E-10

Temp.:

25 °C

Vapour pressure:

0 hPa

Remarks on result:

other: 1x10E-09

Summary of results

The table given below summarizes how the vapour pressure is calculated from the quantities of vaporized test item transported into the trap and the volume of nitrogen which provided the transport. The gas volume under study conditions is calculated from the stated reduced volume ("normalized volume") by substituting the measured temperature and the total saturator column pressure in the general gas equation. The first runs measured at 60 °C (runs 7-9) are not included due to the line.

Vapour pressures calculated from the study data

Test parameters	Quantities of YRC 2388 transported 14) [mg]	Gas volume To.po 15) [ L ]	Temperature T1 [ K ]	Pressure P1 16) [hPa]	Gas volume T1, p1 17) [ L ]	Vapour pressures of YRC 2388 [hPa]                   [Pa]
50°C- 4L/min	0.009294	5716	323.15	1067	6420.08	1.112E-07	1.112E-05
50°C- 2L/min	0.008123	5760	323.15	1060	6512.22	9.577E-08	9.577E-06
50°C-1L/min	0.010740	5760	323.25	1056	6538.91	1.262E-07	1.262E-05
40°C- 4L/min	0.008658	23395	313.35	1066	25503.95	2.527E-08	2.527E-06
40°C-1L/min	0.008286	16317	313.15	1051	18030.10	3.420E-08	3.420E-06
60°C- 4L/min	0.025786	3000	333.35	1066	3479.15	5.870E-07	5.870E-05
60°C- 2L/min	0.005041	500	333.32	1057	584.74	6.828E-07	6.828E-05
60°C- 2L/min	0.007398	500	333.37	1055	585.94	1.000E-06	0.0001000
60°C- 2L/min	0.007769	.500	333.32	1062	581.99	1.057E-06	0.0001057
55°C- 2L/min	0.008040	1000	328.22	1066	1141.87	5.491E-07	5.491 E-05
60°C-1L/min	0.005245	500	333.63	1069	578.72	7.184E-07	7.184E-05

Notes:

14) results from table in previous section, mean from 2 measurements

15) Reduced gas volume under normal conditions, Tg = 273.15 K, p0 = 1013 hPa

16) average air pressure during the run

17) Gas volume under test conditions at temperature T1 and at pressure p1 measured in saturator column.

It follows from the table that the flow rate does not exert a significant influence on the vapour pressures determined. The differences between the results for 1 L/min, 2 L/min and 4 L/min reflect only the statistical error of the method and it was assumed that the flow-rates chosen are sufficiently slow to reach vapour pressure equilibrium in the saturator column. Consequently, all values from the pressures and temperatures given in the table shown above were used for the calculation of a vapour pressure curve according to the Clausius-Clapeyron equation:

log p = a + b x 1/K

The regression coefficients for the Clausius-Clapeyron equation given in the table below was determined by regression calculation using the computer program Statgraphics, version 7.

Results from regression calculation:

	Regression coefficient a	Regression coefficient b	Correlation coefficient	R-squared
Test item	16.9833	- 7698.56	- 0.976545	95.36 %

Using the calculated regression coefficient the partial vapour pressures for 20 and 25 °C shown in the table below are obtained by extrapolation. The corresponding vapour saturation concentrations were calculated by means of the general gas equation.

Vapour Pressures for 20 °C and 25 °C:

Test item

Vapour pressure at 20°C:   5.3x10E-08[Pa] 5.3x10E-10 [hPa]

Vapour concentration at 20°C: 7.6 [ng/m^3]

Vapour pressure at 25°C:   1.5x10E-07[Pa] 1.5x10E-9 [hPa]

Vapour concentration at 25°C: 21 [ng/m^3]

Conclusion

The vapour pressure of YRC 2388 determined at 70, 60, 55, 50 and 40 °C by the gas saturation method according to OECD Guideline No. 104 (corresponding to EEC Guideline A4) yielded by extrapolation of the vapour pressure curve the following vapour pressures and vapour concentrations for 20 and 25 °C:

Test item

Vapour pressure at 20 °C   5x10E-08 [Pa] 5x10E-10 [hPa]

Vapour concentration at 20°C: 7. 6 [ng/m^3]

Vapour pressure at 25°C:   1.0x10E-07[Pa] 1.0x10E-09 [hPa]

Vapour concentration at 25°C: 21 [ng/m^3]

Description of key information

Vapour pressure: 5.0E-10 hPa at 20 °C; 1.0E-9 hPa at 25 °C (OECD Guideline 104, gas saturation method)

Key value for chemical safety assessment

Vapour pressure:

0 hPa

at the temperature of:

25 °C

Additional information

According to Regulation EC No. 440/2008 Method A.4, the vapour pressure values of the test item for the temperatures 20 and 25 °C were calculated by extrapolation of the measured vapour pressure curve.