Registration Dossier
Registration Dossier
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EC number: 200-906-8 | CAS number: 75-83-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because it is an acceptable well-documented publication which meets basic scientific principles.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because it is an acceptable well-documented publication which meets basic scientific principles.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- Pre-GLP study
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 150-300 g - Route of administration:
- oral: gavage
- Details on oral exposure:
-
MAXIMUM DOSE VOLUME APPLIED: 25 ml/kg - Doses:
- up to 25 ml/kg
- No. of animals per sex per dose:
- 6 males
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- Litchfield and Wilcoxen.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 25 mL/kg bw
- Remarks on result:
- other: 16.75 g/kg
- Mortality:
- No mortality at doses up to 25 ml/kg (16.75 g/kg (density 0.67)).
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 for rats is > 25 mL/Kg.
- Executive summary:
This study examined the oral toxicity of commercial hexane. 6 male rats were given doses of up to 25 mL/Kg of test substance by oral gavage. The animals were then observed for 14 days for mortality.
No mortality was observed at any of the doses. The oral LD50 is therefore > 25 mL/Kg (16.75 g/Kg; density of 0.67).
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicological Properties of Hydrocarbon Solvents
- Author:
- Hine, CH, and Zuidema, HH
- Year:
- 1 970
- Bibliographic source:
- Industrial Medicine, Vol. 39, No. 5, May 1970.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- Pre-GLP study
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- C-6 normal and iso paraffins (hexanes) and naphthenes (methyl-cyclohexane, dimethylcyclohexane), 25-35% n-hexane
- IUPAC Name:
- C-6 normal and iso paraffins (hexanes) and naphthenes (methyl-cyclohexane, dimethylcyclohexane), 25-35% n-hexane
- Details on test material:
- - Name of test material (as cited in study report): S-1
- Composition of test material, percentage of components: C-6 normal and iso paraffins (hexanes) and naphthenes (methyl-cyclohexane, dimethylcyclohexane), 25-35% n-hexane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 150-300 g
Administration / exposure
- Route of administration:
- oral: gavage
- Details on oral exposure:
-
MAXIMUM DOSE VOLUME APPLIED: 25 ml/kg - Doses:
- up to 25 ml/kg
- No. of animals per sex per dose:
- 6 males
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- Litchfield and Wilcoxen.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 25 mL/kg bw
- Remarks on result:
- other: 16.75 g/kg
- Mortality:
- No mortality at doses up to 25 ml/kg (16.75 g/kg (density 0.67)).
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 for rats is > 25 mL/Kg.
- Executive summary:
This study examined the oral toxicity of commercial hexane. 6 male rats were given doses of up to 25 mL/Kg of test substance by oral gavage. The animals were then observed for 14 days for mortality.
No mortality was observed at any of the doses. The oral LD50 is therefore > 25 mL/Kg (16.75 g/Kg; density of 0.67).
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