4'-Ethyl-2,3-difluorbiphenyl-4-boronic acid

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

other:

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

4'-Ethyl-2,3-difluorbiphenyl-4-boronic acid

EC Number:

929-209-3

Cas Number:

1123312-95-7

Molecular formula:

C14 H13 B F2 O2

IUPAC Name:

4'-Ethyl-2,3-difluorbiphenyl-4-boronic acid

Applicant's summary and conclusion

Executive summary:

Resorption

Because of the molecular structure, low molecular weight and octanol-water partition coefficient (4.3), resorption of the test item via the gastrointestinal tract is considered to be likely. After single treatment of rats with the test item the LD50 was between 300 and 2000 mg/kg bw (acute oral: key study).

Data from a subacute reproductive combination study (OECD 422) of the test item are available (dosing 25, 100, and 400 mg/kg/d). In this study, tubulopathy correlated with increased kidneys weights and grossly visible enlarged kidneys and was considered to be of adverse nature. Predominantly, morbidity and mortality of the adult males and females in this study was considered to be related to the observed tubulopathy. No adverse effects of the test item were noted at a dose level of 25 mg/kg body weight/day. Thus, the NOAEL for general systemic toxicity as well as for developmental toxicity could be established at 25 mg/kg body weight/day.

From these effects it can be concluded that the test item is resorbed after oral administration.

Distribution

Due to the low water solubility and the high octanol/water-coefficient, in combination with the low molecular weight, permeation of membranes is assumed to be possible. The toxicological effects found in the repeat dose toxicity study of the test item (OECD 422: key study) clearly show that this compound is distributed throughout the body after oral uptake and is thus systemically available.

Metabolism and Excretion

Specific information on the metabolism and excretion of the substance is not available. From the subacute study it can be conclududed, that metabolism in the liver can be assumed based on the morphological changes obeserved. The tubulopathy correlated with increased kidneys weights and grossly visible enlarged kidneys suggests that extcretion via kidneys is the main route of elimination.