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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin corrosion: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is a strong acid (pH ≤ 2.0) or base (pH ≥ 11.5) and the available information indicates that it should be classified as skin corrosion (Category 1, 1A, 1B or 1C)
Justification for type of information:
A 50g/L solution of the substance has a pH of 1.2, therefore it can be considered to be corrosive for the purpose of CLP classification
Cross-reference
Reason / purpose for cross-reference:
data waiving: supporting information
Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Justification for type of information:
In-house data assessment.
Solublity assessed at different pH and assessed in hardened water
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Principles of method if other than guideline:
Solubility at range of pH was investigated as has relevance for environmental and toxicological assessments.
Solublity in hardend water at low concentrations was also assessed for environmental relevance
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
Batch No : D-02-4057
Key result
Water solubility:
> 500 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
ca. 1.9
Remarks on result:
completely miscible
Remarks:
pH unadjusted
Water solubility:
> 20 g/L
Conc. based on:
test mat. (total fraction)
Temp.:
20 °C
pH:
ca. 3
Remarks on result:
other: pH buffered for evaluation of solubility at different pH
Water solubility:
< 1 g/L
Conc. based on:
test mat. (total fraction)
Temp.:
20 °C
pH:
ca. 4
Remarks on result:
other: Buffered to pH 4
Water solubility:
< 100 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
100 mg/L
Temp.:
20 °C
pH:
ca. 3
Remarks on result:
other: Environmental hardness ca 100 mg/l caCO3
Water solubility:
ca. 1 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 mg/L
Temp.:
20 °C
pH:
4.3
Remarks on result:
other: Evironmental hardness ca 100 mg CaCO3
Details on results:
The data indicate reduced solubility in water when buffered to > pH 3
When repeated in hardened water, but no buffer, solublity was ca 1 mg/l based on test material, with a pH of 4.3 recorded.
A loading of 20 g/l in distilled water, buffered to pH 3 was soluble, but when 1 g/l was in hardened water, it was insoluble at pH 3
Conclusions:
The solubility is pH dependant with reduced solublity at pH 4 or more, suggesting formation of hydroxide / oxide
The substance supplied is typically in acidic solution
The data indicate reduced solubility in water when buffered to > pH 3
When repeated in hardened water, but no buffer, solublity was ca 1 mg/l based on test material, with a pH of 4.3 recorded.
A loading of 20 g/l in distilled water, buffered to pH 3 was soluble, but when 1 g/l was in hardened water, it was insoluble at pH 3

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion