Diammonium dihydroxybis[lactato(2-)-O1,O2]titanate(2-)

Endpoint summary

Description of key information

In vivo study: LD50 17 000 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Sept 28 1978-Dec 15 1978

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test material, as an aqeous solution, was administered to one rat per dose level by intragastric intubation. Later in the day, rats were checked for clinical signs of toxicity. Survivors were weighed and observed daily until signs of toxicity subsided, and then at least every other day through a 14-day recovery period. Rats were then sacrificed.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Specific details on test material used for the study:

50% Titanium lactate (Tyzor LA), ammonium salt, 50% water

Species:

rat

Strain:

other: Crl:CD

Sex:

male

Details on test animals or test system and environmental conditions:

7-week-old rats were received from Charles River Breeding laboratories, Kingston, New York.

Route of administration:

oral: gavage

Vehicle:

water

Doses:

670, 2250, 3400, 5000, 7500, 11000, 17000 and 25000 mg/kg bw.

No. of animals per sex per dose:

One

Control animals:

no

Key result

Sex:

male

Dose descriptor:

other: Approximate lethal dose

Effect level:

17 000 mg/kg bw

Based on:

test mat. (total fraction)

Mortality:

Mortality occured 4 days after dosing of 17 000 mg/kg bw. Mortality occurred in 1 hour after dosing of 25 000 mg/kg bw.

Clinical signs:

other: Rats exhibited diarrhea at dose level 3400 mg/kg bw. At dose levels 17 000 and 25 000 mg/kg bw clinical signs included decreased muscle tone, diarrhea, lethargy, no light reflex, gasping, pallor, red ocular discharge, and brown-stained fur aroung the nose

Gross pathology:

Not specified.

Interpretation of results:

GHS criteria not met

Conclusions:

An approximate lethal dose for Tyzor LA was determined to be 17 000 mg/kg body weight.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

discriminating dose

Value:

17 000 mg/kg bw

Additional information

The test material, as an aqeous solution, was administered to one rat per dose level 670, 2250, 3400, 5000, 7500, 11000, 17000 and 25000 mg/kg bw by intragastric intubation. Later in the day, rats were checked for clinical signs of toxicity. Survivors were weighed and observed daily until signs of toxicity subsided, and then at least every other day through a 14-day recovery period. Rats were then sacrificed.

Mortality occured 4 days after dosing of 17 000 mg/kg bw. Mortality occurred in 1 hour after dosing of 25 000 mg/kg bw.

Justification for classification or non-classification

An approximate lethal dose for diammonium dihydroxybis[lactato (2-)-O1,O2]titanate(2-), Tyzor LA was determined to be 17 000 mg/kg body weight.No classification is warranted.