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EC number: 255-350-9
CAS number: 41395-83-9
short term toxicity towards aquatic invertebrates based on read across
from CAS 68583-51-7 and CAS 853947-59-8
There is no study available,
in which the short-term toxicity of propylene dinonanoate (CAS
41395-83-9) to aquatic invertebrates was investigated. Therefore,
read-across to the structurally related source decanoic acid, mixed
diesters with octanoic acid and propylene glycol (CAS 68583-51-7) and
butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) was performed
in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The
source substances are characterized by similar fatty acid chain lengths
as well as alcohol components and are therefore considered suitable
representatives for the assessment of the short-term toxicity of the
target substance to aquatic invertebrates. A detailed read-across
justification is provided in the analogue justification in IUCLID
All available studies with
the source substances were performed according to appropriate EU
guidelines and GLP.
One experimental study
investigating the short-term toxicity of the source substance decanoic
acid, mixed diesters with octanoic acid and propylene glycol (CAS
68583-51-7) to aquatic invertebrates is available (1995). It was
performed according to EU Method C.2 (GLP) with Daphnia magna in a
static exposure regime. The test species were exposed to a Water
Accommodated Fraction (WAF) of 1000 mg/L (nominal) for 48 h. A DOC
analysis of the WAF resulted in a test substance concentration of 2.4
mg/L (meas. geom. mean). Since no effects were observed after 48 h an
EC50 of > 2.4 mg/L (meas. geom. mean) was derived.
A further study is available
testing the short-term toxicity of the source substance butylene glycol
dicaprylate / dicaprate (CAS 853947-59-8) to aquatic invertebrates
according to EU Method C.2 and GLP (1997). Daphnia magna as the test
organism was exposed in a limit test to 1000 mg test item/L (WAF) and a
control for 48 h. The concentration of the stock solution was measured
via TOC and was 2.2 mg/L (0 h). The recovery rate in the stability test
was > 80% and the concentration after 48 and 72 h did not differ more
than 20%. Therefore, the test substance was bioavailable throughout the
test. No toxicity effects were recorded resulting in an EL50 (48 h) >
1000 mg/L (nominal, WAF).
data with the source substances consistently showed no toxicity effects
towards aquatic invertebrates up to the water solubility limit. Based on
the structural and chemical similarity of the target and source
substances, the target substance is expected to exhibit a similar
ecotoxicological profile. Therefore, it can be concluded that propylene
dinonanoate (CAS 41395-83-9) will not cause short-term effects to
aquatic invertebrates up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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